BMS-191011
BMS 191011 (BMS-A) is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel) . BMS-191011 shows neuroprotective activities in rodent models of stroke[1].
Product Specifications
CAS Number
202821-81-6
Product Name Alternative
BMS-A
UNSPSC
12352005
Hazard Statement
H301, H413
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bms-191011.html
Purity
99.56
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1OC(C2=CC=C(C(F)(F)F)C=C2)=NN1CC3=CC(Cl)=CC=C3O
Molecular Formula
C16H10ClF3N2O3
Molecular Weight
370.71
Precautions
H301, H413
References & Citations
[1]Romine JL, et al. 3-[ (5-Chloro-2-hydroxyphenyl) methyl]-5-[4- (trifluoromethyl) phenyl ]-1,3,4-oxadiazol-2 (3H) -one, BMS-191011: opener of large-conductance Ca (2+) -activated potassium (maxi-K) channels, identification, solubility, and SAR. J Med Chem. 2007 Feb 8;50 (3) :528-42.|[2]Asami Mori, et al. BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Biol Pharm Bull. 2011;34 (1) :150-2.|[3]Remigante A, et al. NS-11021 Modulates Cancer-Associated Processes Independently of BK Channels in Melanoma and Pancreatic Duct Adenocarcinoma Cell Lines. Cancers (Basel) . 2021 Dec 6;13 (23) :6144.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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