Sulfo-LC-SPDP (sodium)
Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[169751-10-4]
UNSPSC
12352203
Hazard Statement
H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sulfo-lc-spdp-sodium.html
Purity
95.0
Solubility
DMSO : ≥ 100 mg/mL|H2O : 10 mg/mL (ultrasonic)
Smiles
O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCCNC(CCSSC2=NC=CC=C2)=O
Molecular Formula
C18H22N3NaO8S3
Molecular Weight
527.57
Precautions
H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Available Sizes
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