Atg4B-IN-2
Atg4B-IN-2 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition[1].
Product Specifications
CAS Number
2765008-88-4
UNSPSC
12352005
Target
Atg4; Autophagy; Cathepsin; Phospholipase
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atg4b-in-2.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1)CCCCCCCCCCC)/C=C/C(O)=O
Molecular Formula
C21H30O3
Molecular Weight
330.46
References & Citations
[1]Kudo Y, Endo S, Fujita M, et al. Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2022;65 (6) :4878-4892.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP304770M 100 µg
TTC35 (EMC2) (NM_014673) Human Recombinant Protein
Sign In for Pricing
View Details 
P024-488A-100UL 1x 100 µL
6X His Tag Recombinant Monoclonal Mouse Antibody (2405.H6), CF®488A Conjugate - Biotium Choice
Sign In for Pricing
View Details 
BNC881927-500 1x 500 µL
SOX9 / SRY-box 9 (PCRP-SOX9-1A2), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![LDHA Rabbit Monoclonal Antibody [Clone ID: R06-6J2]](https://cdn.genprice.uk/products/937/6868c2cf994c49e6dc3e7768/imageurl/ta384653.webp)
TA384653 100 µL
LDHA Rabbit Monoclonal Antibody [Clone ID: R06-6J2]
Sign In for Pricing
View Details 