NPFF1-R antagonist 1

NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively[1].

Product Specifications

CAS Number

[3057753-40-6]

UNSPSC

12352005

Target

Neuropeptide FF Receptor; Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/npff1-r-antagonist-1.html

Solubility

10 mM in DMSO

Smiles

O=C(CN1CCC(CC2=CC=CC=C2)CC1)NCC3(CCN(CC4=CC=CC=C4)CC3)NC5=C(C=CC=C6)C6=CC=C5

Molecular Formula

C37H44N4O

Molecular Weight

560.77

References & Citations

[1]Galal KA, et al. Guanidine-to-piperidine switch affords high affinity small molecule NPFF ligands with preference for NPFF1-R and NPFF2-R subtypes. Eur J Med Chem. 2024 Apr 5;269:116330.