NPFF1-R antagonist 1
Product Specifications
UNSPSC Description
NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively[1].
Target Antigen
Neuropeptide FF Receptor; Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/npff1-r-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C(CN1CCC(CC2=CC=CC=C2)CC1)NCC3(CCN(CC4=CC=CC=C4)CC3)NC5=C(C=CC=C6)C6=CC=C5
Molecular Weight
560.77
References & Citations
[1]Galal KA, et al. Guanidine-to-piperidine switch affords high affinity small molecule NPFF ligands with preference for NPFF1-R and NPFF2-R subtypes. Eur J Med Chem. 2024 Apr 5;269:116330.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161405/NPFF1-R-antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161405/
Clinical Information
No Development Reported
Curated Selection
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