MC-ND-18
MC-ND-18 is an ATTEC degrader of NLRP3 through autophagic mechanisms, with the DC50 of 125.5 nM in THP-1 cell. MC-ND-18 is composed of a NLRP3 ligand, linker and LC3 ligand[1].
Product Specifications
CAS Number
3081572-53-1
UNSPSC
12352005
Target
ATTECs; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Autophagy; Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mc-nd-18.html
Smiles
IC1=CC=C(C(/C(C2=O)=C/C3=CC(Br)=C(O)C(Br)=C3)=C1)N2CCOCCOCCOCCOC4=CC=C(S(NC(NC5=C6C(CCC6)=CC7=C5CCC7)=O)(=O)=O)C=C4
Molecular Formula
C42H42Br2IN3O9S
Molecular Weight
1051.58
References & Citations
[1]Kai Yin, et al. Discovery of autophagy-tethering compounds as potent NLRP3 degraders for IBD Immunotherapy. Eur J Med Chem. 2024 Sep 5:275:116581.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Frequently Asked Questions
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