Tubulin polymerization-IN-47

Tubulin polymerization-IN-47 (Compound 4h) is a tubulin polymerization inhibitor and mitotic inhibitor. Tubulin polymerization-IN-47 inhibits neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 and Kelly cell line[1].

Product Specifications

CAS Number

[2834087-62-4]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-47.html

Purity

99.51

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC(C2=NC=CN3C=C(C4=CC=C(C)C=C4)N=C32)=CC(OC)=C1OC

Molecular Formula

C22H21N3O3

Molecular Weight

375.42

References & Citations

[1]Joshua Thammathong, et al. Fused Imidazopyrazine-Based Tubulin Polymerization Inhibitors Inhibit Neuroblastoma Cell Function. ACS Med. Chem. Lett. 2023.