Tubulin polymerization-IN-47
Tubulin polymerization-IN-47 (Compound 4h) is a tubulin polymerization inhibitor and mitotic inhibitor. Tubulin polymerization-IN-47 inhibits neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 and Kelly cell line[1].
Product Specifications
CAS Number
[2834087-62-4]
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-47.html
Purity
99.51
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC(C2=NC=CN3C=C(C4=CC=C(C)C=C4)N=C32)=CC(OC)=C1OC
Molecular Formula
C22H21N3O3
Molecular Weight
375.42
References & Citations
[1]Joshua Thammathong, et al. Fused Imidazopyrazine-Based Tubulin Polymerization Inhibitors Inhibit Neuroblastoma Cell Function. ACS Med. Chem. Lett. 2023.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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