L82
L82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) . L82 shows anti-proliferative activity to breast cancer cells[1][2].
Product Specifications
CAS Number
[329227-30-7]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l82.html
Concentration
10mM
Purity
98.89
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1NN=CC(N/N=C/C2=CC=C(C([N+]([O-])=O)=C2)O)=C1Cl
Molecular Formula
C11H8ClN5O4
Molecular Weight
309.67
References & Citations
[1]Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst) . 2017 Dec;60:29-39.|[2]Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68 (9) :3169-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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