Bintrafusp alfa

Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer[1].

Product Specifications

CAS Number

[1918149-01-5]

Product Name Alternative

M7824; MSB0011359C

UNSPSC

12352203

Target

TGF-β Receptor

Type

Inhibitory Antibodies

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bintrafusp-alfa.html

Purity

97.96

Solubility

H2O

Smiles

[Bintrafuspalfa]

Molecular Weight

(177.21 kDa)

References & Citations

[1]Strauss J, et, al. Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies. J Immunother Cancer. 2020 Dec;8 (2) :e001395.