VU0652925
VU0652925, an analog of BMS986120, is a PAR4 antagonist, with IC50 values of 43 pM and 39.2 pM for PAC1 and P-selectin, respectively. VU0652925 is able to suppress GPIIbIIIa activation[1].
Product Specifications
CAS Number
1476847-58-1
UNSPSC
12352005
Target
Protease Activated Receptor (PAR) ; P-selectin
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vu0652925.html
Smiles
COC1=NN2C(S1)=NC(C3=CC4=C(C=C(C=C4OCC5=CSC(C6=CC=CC=C6)=N5)OC)O3)=C2
Molecular Formula
C24H18N4O4S2
Molecular Weight
490.55
References & Citations
[1]Matthew T Duvernay, et al. Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets. Mol Pharmacol. 2017 Jan;91 (1) :39-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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