Folitixorin (calcium)
Folitixorin calcium is a cofactor and an analog of leucovorin. Folitixorin calcium is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2].
Product Specifications
CAS Number
133978-75-3
Product Name Alternative
5,10-Methylenetetrafolate (calcium) ; ANX-510
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/folitixorin-calcium.html
Smiles
O=C1C2=C(NCC3N2CN(C4=CC=C(C(N[C@]([H])(C([O-])=O)CCC([O-])=O)=O)C=C4)C3)NC(N)=N1.[Ca+2]
Molecular Formula
C20H21CaN7O6
Molecular Weight
495.50
References & Citations
[1]Costantini CL, et al. Resection of hepatic metastasis after 5-fluorouracil and cofactor for colon cancer. Hepatogastroenterology. 2009;56 (91-92) :645-649.|[2]Carlsson G, et al. 5-fluorouracil (5-FU) and 5,10-methylene tetrahydrofolate (5,10-CH2FH4) as adjuvant therapy in an experimental rodent colon carcinoma model. Anticancer Res. 1997;17 (5A) :3671-3674.|[3]Botto LD, et al. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000;151 (9) :862-877.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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