HUP1-IN-1 (potassium)
HUP1-IN-1 potassium (compound 6a) is a hUP1 inhibitor with Kii and Kis Urd of 375 and 635 nM. hUP1-IN-1 potassium showes inhibitory activities over hUP1 catalyzed reaction with 70% at 1 μM. hUP1-IN-1 potassium can be used for the research of cancer[1].
Product Specifications
CAS Number
[118803-30-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphorylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hup1-in-1-potassium.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
N#CC1=C(C)C=C(O[K])NC1=O
Molecular Formula
C7H5KN2O2
Molecular Weight
188.23
Precautions
H315, H319, H335
References & Citations
[1]Renck D, et al. Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. J Med Chem. 2013 Nov 14;56 (21) :8892-902.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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