7,3',4'-Trihydroxy-3-benzyl-2H-chromene

7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus[1][2].

Product Specifications

CAS Number

[1111897-60-9]

UNSPSC

12352005

Target

Influenza Virus

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/7-3-4-trihydroxy-3-benzyl-2h-chromene.html

Purity

95.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C(OC2)=C1)C=C2CC3=CC(O)=C(O)C=C3

Molecular Formula

C16H14O4

Molecular Weight

270.28

References & Citations

[1]Hyung Jae Jeong, et al. Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition. Biol Pharm Bull. 2012;35 (5) :786-90. |[2]Huanxin Zhao, et al. A new homoisoflavan from Caesalpinia sappan. J Nat Med. 2008 Jul;62 (3) :325-7.