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OSM-S-106

OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. OSM-S-106 inhibits protein translation and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and low intrinsic clearance by human microsomes[1].

Product Specifications

CAS Number

2650846-59-4

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/osm-s-106.html

Purity

99.34

Solubility

10 mM in DMSO

Smiles

NC1=C2C(C=C(C3=CC(S(N)(=O)=O)=CC=C3)S2)=NC=N1

Molecular Formula

C12H10N4O2S2

Molecular Weight

306.36

References & Citations

[1]Xie SC, et al. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Preprint. Res Sq. 2023; rs.3.rs-3198291. Published 2023 Jul 27.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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