OSM-S-106
OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. OSM-S-106 inhibits protein translation and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and low intrinsic clearance by human microsomes[1].
Product Specifications
CAS Number
[2650846-59-4]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/osm-s-106.html
Purity
99.34
Solubility
10 mM in DMSO
Smiles
NC1=C2C(C=C(C3=CC(S(N)(=O)=O)=CC=C3)S2)=NC=N1
Molecular Formula
C12H10N4O2S2
Molecular Weight
306.36
References & Citations
[1]Xie SC, et al. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Preprint. Res Sq. 2023; rs.3.rs-3198291. Published 2023 Jul 27.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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