AKR1C3-IN-12

AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer[1].

Product Specifications

CAS Number

[891075-67-5]

UNSPSC

12352005

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/akr1c3-in-12.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(OC1=N)C(O)=CC=C2)NC3=CC=C(C)C=C3

Molecular Formula

C17H14N2O3

Molecular Weight

294.30

References & Citations

[1]Rin Himura, et al. Inhibition of aldo-keto reductase 1C3 overcomes gemcitabine/cisplatin resistance in bladder cancer. Chem Biol Interact. 2024 Jan 25:388:110840.