Hydroxycitric acid

Hydroxycitric acid is the major active ingredient of Garcinia cambogia. Hydroxycitric acid competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4].

Product Specifications

CAS Number

[6205-14-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ATP Citrate Lyase; HIF/HIF Prolyl-Hydroxylase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hydroxycitric-acid-1.html

Purity

98.79

Solubility

10 mM in DMSO

Smiles

OC(C(C(O)=O)O)(C(O)=O)CC(O)=O

Molecular Formula

C6H8O8

Molecular Weight

208.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3. |[2]Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20 (20) . pii: E5049.|[3]Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667.|[4]Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280 (18) :1596-600.