BI-671800
BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively[1]. BI-671800 has potential for the treatment of poorly controlled asthma[2].
Product Specifications
CAS Number
1093108-50-9
Product Name Alternative
Cyclopamine-KAAD
UNSPSC
12352005
Target
CRTH2 (GPR44) ; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/BI-671800.html
Concentration
10mM
Purity
99.36
Solubility
DMSO : 135 mg/mL (ultrasonic)
Smiles
O=C(O)CC1=C(N(C)C)N=C(CC2=CC=C(NC(C3=CC=C(C(F)(F)F)C=C3)=O)C=C2)N=C1N(C)C
Molecular Formula
C25H26F3N5O3
Molecular Weight
501.50
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
DP
Available Sizes
Frequently Asked Questions
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