(rac) -AR-13503
(rac) -AR-13503 ((rac) -AR-13324 M1 metabolite) is the isoform of AR-13503. AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice[1][2].
Product Specifications
CAS Number
1254032-16-0
Product Name Alternative
(rac) -AR-13324 M1 metabolite
UNSPSC
12352005
Target
PKC; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rac-ar-13503.html
Purity
99.08
Solubility
1 M HCl : 25 mg/mL (ultrasonic) |DMSO : 40 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C)
Smiles
O=C(C(CN)C1=CC=C(CO)C=C1)NC2=CC3=C(C=C2)C=NC=C3
Molecular Formula
C19H19N3O2
Molecular Weight
321.37
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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