IRAK inhibitor 4

IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor.

Product Specifications

CAS Number

[1012104-68-5]

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/IRAK-inhibitor-4.html

Purity

99.77

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

OC1CCC(N2C3=C(C=C(C=C3)C(NCCC(C)C)=O)N=C2NC4=NNC5=C4C=C(C=C5)C6=CC=CC=C6OC(F)(F)F)CC1

Molecular Formula

C33H35F3N6O3

Molecular Weight

620.66

References & Citations

[1]Marinho FV, et al. Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection. J Immunol. 2016 Sep 1;197 (5) :1852-63.|[2]Talreja J, et al. Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells. J Immunol. 2016 Aug 15;197 (4) :1368-78.|[3]Li Z, et al. Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. J Clin Invest. 2015 Mar 2;125 (3) :1081-97.