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Picolinamide

Picolinamide (2-Picolinamide) is an inhibitor of Poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3].

Product Specifications

CAS Number

1452-77-3

Product Name Alternative

2-Picolinamide

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/picolinamide.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NC=CC=C1)N

Molecular Formula

C6H6N2O

Molecular Weight

122.13

Precautions

H315, H319, H335

References & Citations

[1]Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251 (1) :188-92. |[2]Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly (ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257 (11) :6084-8. |[3]Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95 (1) :474-81. |[4]amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly (adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45 (4) :1845-9.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature 3 years

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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