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Human GCGR Protein, Flag, His Tag (Detergent)

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of type 2 diabetes mellitus (T2DM) . The ever increasing prevalence of type 2 diabetes mellitus in the developed and developing nations calls for the introduction of new and more effective treatments. Glucagon receptor (GCGR) antagonists are highly validated in preclinical models of T2DM and thus have the potential to be developed as a new therapy.

Product Specifications

Background

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of type 2 diabetes mellitus (T2DM) . The ever increasing prevalence of type 2 diabetes mellitus in the developed and developing nations calls for the introduction of new and more effective treatments. Glucagon receptor (GCGR) antagonists are highly validated in preclinical models of T2DM and thus have the potential to be developed as a new therapy.

Specifications

This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 83.2 kDa.

Accession Number

P47871-1

Expression Region

Ala 26 - Ala 256 & Glu 260 - Asn 432

Host

HEK293

Target

GCGR

Conjugation

Unconjugated

Tag

N-Flag & C-10xHis

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Bioactivity

Immobilized Human GCGR Protein, Flag,His Tag (Cat. No. GCR-H52D3) at 5 μg/mL (100 μL/well) on a Nickel Coated plate can bind Monoclonal Anti-Human GCGR antibody, Human IgG2 (Volagidemab) (Cat. No. GCR-H52D3) with a linear range of 0.1-3 ng/mL (QC tested).

Format

Liquid

Buffer

50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5

Additives

Glycerol

Molecular Weight

83.2 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

Dry ice

Storage Conditions

-70°C

Package Size

100ug*1

Host or Source

HEK293

Species

Human

Protein ID

P47871-1

Preservative

Glycerol

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