Imidazolidinyl urea

Imidazolidinyl urea is a commonly used antibacterial preservative in cosmetics and pharmaceuticals that releases formaldehyde through decomposition. Imidazolidinyl urea can also be used in the preparation of multifunctional hydrogels for the care of infectious wounds. Imidazolidinyl urea has broad-spectrum antibacterial activity, which mainly inhibits the reproduction of gram-negative bacteria and gram-positive bacteria, and restricts the growth of yeast and mold to a certain extent. Imidazolidinyl urea can induce non-histaminergic allergy by MRGPRX2 activation of mast cells[1][2][3].

Product Specifications

CAS Number

[39236-46-9]

UNSPSC

12352005

Hazard Statement

H317

Target

Bacterial; Interleukin Related; Mas-related G-protein-coupled Receptor (MRGPR)

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Imidazolidinyl-urea.html

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(NC(C(N1)=O)N(CO)C1=O)NCNC(NC(C(N2)=O)N(CO)C2=O)=O

Molecular Formula

C11H16N8O8

Molecular Weight

388.29

Precautions

H317

References & Citations

[1]Doi T, et al. Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials. Contact Dermatitis. 2012 Nov;67 (5) :284-92.|[2]Gao J, et al. Imidazolidinyl urea activates mast cells via MRGPRX2 to induce non-histaminergic allergy. Toxicol Res (Camb) . 2021 Apr 29;10 (3) :467-475.|[3]Wu Q, et al. On-demand imidazolidinyl urea-based tissue-like, self-healable, and antibacterial hydrogels for infectious wound care. Bioact Mater. 2024 Oct 15;44:116-130.