R1487 (Hydrochloride)
R1487 Hydrochloride is a highly potent and selective p38α inhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β, respectively[1].
Product Specifications
CAS Number
[449808-64-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; p38 MAPK
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/R1487-Hydrochloride.html
Purity
98.96
Solubility
DMSO : 20.83 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C.Cl
Molecular Formula
C19H19ClF2N4O3
Molecular Weight
424.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Goldstein DM et al. Discovery of 6- (2,4-difluorophenoxy) -2-[3-hydroxy-1- (2-hydroxyethyl) propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6- (2,4-difluorophenoxy) -8-methyl-2- (tetrahydro-2H-pyran-4-ylamino) pyrido[2,3-d]pyrimidin-7 (8H) -one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54 (7) :2255-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
P38α; p38β
Available Sizes
Curated Selection
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