R1487 (Hydrochloride)

R1487 Hydrochloride is a highly potent and selective p38α inhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β, respectively[1].

Product Specifications

CAS Number

[449808-64-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; p38 MAPK

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/R1487-Hydrochloride.html

Purity

98.96

Solubility

DMSO : 20.83 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C.Cl

Molecular Formula

C19H19ClF2N4O3

Molecular Weight

424.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Goldstein DM et al. Discovery of 6- (2,4-difluorophenoxy) -2-[3-hydroxy-1- (2-hydroxyethyl) propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6- (2,4-difluorophenoxy) -8-methyl-2- (tetrahydro-2H-pyran-4-ylamino) pyrido[2,3-d]pyrimidin-7 (8H) -one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54 (7) :2255-65.