Anisatin

Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM[1].

Product Specifications

CAS Number

[5230-87-5]

UNSPSC

12352005

Hazard Statement

H300+H330

Target

GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/anisatin.html

Purity

99.0

Smiles

O[C@]12[C@]3([C@@H](C[C@H]2O)C)C[C@@H](OC([C@@H]3O)=O)[C@](O)([C@]14C(OC4)=O)C

Molecular Formula

C15H20O8

Molecular Weight

328.31

Precautions

P260-P264-P270-P271-P284-P304+P340-P330-P403+P233-P405-P501

References & Citations

[1]Ikeda T, et al. Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons. Br J Pharmacol. 1999;127 (7) :1567-1576.|[2]Bao X, et al. Bioavailability and Pharmacokinetics of Anisatin in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry. Biomed Res Int. 2020;2020:8835447. Published 2020 Dec 23.