Diphenylcyclopropenone

Diphenylcyclopropenone (Diphencyprone) is a potent hapten acting as a topical immunomodulatory agent, which induces an allergic contact dermatitis. Diphenylcyclopropenone induces an increase of cell-surface thiols in cells of a human monocytic cell line, THP-1. Diphenylcyclopropenone acts on the autoreactive T-lymphocytes within the follicular milieu to induce Apoptosis. Diphenylcyclopropenone can be used for alopecia areata research[1][2][3][4].

Product Specifications

CAS Number

[886-38-4]

Product Name Alternative

Diphencyprone

UNSPSC

12352005

Hazard Statement

H317

Target

Apoptosis; Interleukin Related; IRE1; p38 MAPK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/diphenylcyclopropenone.html

Purity

99.95

Solubility

Acetone : ≥ 50 mg/mL|DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=CC=C2)=C1C3=CC=CC=C3

Molecular Formula

C15H10O

Molecular Weight

206.24

Precautions

H317

References & Citations

[1]Yugang Gong, et al. Diphenylcyclopropenone plays an effective therapeutic role by up-regulating the TSLP/OX40L/IL-13 pathway in severe alopecia areata. Exp Dermatol. 2021 Feb;30 (2) :278-283.|[2]Zekayi Kutlubay, et al. Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata. Turk J Med Sci. 2020 Dec 17;50 (8) :1817-1824.|[3]Hirota M, et al. Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone. J Toxicol Sci. 2010 Dec;35 (6) :871-9.|[4]Svalgaard JD, et al. Systemic immunogenicity of para-Phenylenediamine and Diphenylcyclopropenone: two potent contact allergy-inducing haptens. Immunol Res. 2014 Jan;58 (1) :40-50.