HTH-01-015
HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM) . HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM) .
Product Specifications
CAS Number
[1613724-42-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HTH-01-015.html
Purity
98.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C=C2C=CC=CC2=C3)=C3N(C)C4=NC(NC5=CN(N=C5)C6CCNCC6)=NC(C)=C4N1C
Molecular Formula
C26H28N8O
Molecular Weight
468.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Banerjee S, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457 (1) :215-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NUAK1
Available Sizes
Curated Selection
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