HTH-01-015
Product Specifications
UNSPSC Description
HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).
Target Antigen
AMPK
Type
Reference compound
Related Pathways
Epigenetics;PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HTH-01-015.html
Purity
98.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C=C2C=CC=CC2=C3)=C3N(C)C4=NC(NC5=CN(N=C5)C6CCNCC6)=NC(C)=C4N1C
Molecular Weight
468.55
References & Citations
[1]Banerjee S, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12334/HTH-01-015-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12334/HTH-01-015-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1613724-42-7
Available Sizes
Curated Selection
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