HTH-01-015

HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM) . HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM) .

Product Specifications

CAS Number

[1613724-42-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK

Type

Reference compound

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HTH-01-015.html

Purity

98.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(C=C2C=CC=CC2=C3)=C3N(C)C4=NC(NC5=CN(N=C5)C6CCNCC6)=NC(C)=C4N1C

Molecular Formula

C26H28N8O

Molecular Weight

468.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Banerjee S, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457 (1) :215-25.