Valproic acid (Standard)

Valproic acid (Dipropylacetic Acid) (Standard) is an analytical standard for valproic acid. This product is intended for research and analytical applications. Valproic acid is an orally active HDAC inhibitor (IC50=0.5-2 mM), inhibits the activity of HDAC1 (IC50=400 μM), and induces the degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits the proliferation of small cell lung cancer (SCLC) cells. Valproic acid is used in the study of epilepsy, bipolar disorder, metabolic diseases, HIV infection, and migraine[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[99-66-1]

Product Name Alternative

VPA (Standard) ; 2-Propylpentanoic acid (Standard) ; Dipropylacetic acid (Standard)

UNSPSC

12352211

Target

Apoptosis; Autophagy; Endogenous Metabolite; HDAC; HIV; Mitophagy; Notch; Organoid; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/valproic-acid-standard.html

Purity

99.97

Smiles

CCCC(CCC)C(O)=O

Molecular Formula

C8H16O2

Molecular Weight

144.21

References & Citations

[1]Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30 (6) :2999-3005.|[2]Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276 (39) :36734-41.|[3]Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.|[4]Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31 (8) :740-50.|[5]Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85 (1) :1-10.|[6]Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148 (1) :31-7.|[7]Routy JP, et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med. 2012 May;13 (5) :291-6.