MM 54
MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation[1][2].
Product Specifications
CAS Number
1313027-43-8
UNSPSC
12352209
Target
Apelin Receptor (APJ)
Type
Peptides
Related Pathways
GPCR/G Protein
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mm-54.html
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H]1CCCNC(N)=N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H]3NC([C@@H](NC([C@@H](NC([C@@]4([H])N(CCC4)C([C@@H](NC([C@H](CSSC3)N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)=O)CC5=CN=CN5)=O)C(O)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)([H])CCC2
Molecular Formula
C70H121N29O15S4
Molecular Weight
1737.16
References & Citations
[1]N J Maximilian Macaluso, et al. Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem. 2011 Jun 6;6 (6) :1017-23.|[2]Elizabeth Harford-Wright, et al. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 2017 Nov 1;140 (11) :2939-2954.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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