GKA50
GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) . GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats[1][2][3][4].
Product Specifications
CAS Number
851884-87-2
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Glucokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gka50.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 46 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=CC=C(NC(C2=CC(O[C@@H](C)CC3=CC=CC=C3)=CC(O[C@@H](C)COC)=C2)=O)N=C1)O
Molecular Formula
C26H28N2O6
Molecular Weight
464.51
Precautions
H302, H413
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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