Brimonidine (tartrate)
Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.
Product Specifications
CAS Number
70359-46-5
Product Name Alternative
UK 14304 (tartrate) ; AGN190342 (tartrate)
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology; Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/UK-14,304-tartrate.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H](O)[C@@H](O)C(O)=O.BrC1=C2N=CC=NC2=CC=C1NC3=NCCN3
Molecular Formula
C15H16BrN5O6
Molecular Weight
442.22
Precautions
H301, H315, H319, H335
References & Citations
[1]Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43 (22) : p. 1805-12.|[2]Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72 (4) : p. 413-5.|[3]Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288 (2) : p. 798-804.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
Citation 01
Cell Rep. 2019 Dec 3;29 (10) :2929-2935.e4|Int J Pharm. 2022 Feb 5:613:121361.|J Ocul Pharmacol Ther. 2023 Sep;39 (7) :456-462.|J Ocul Pharmacol Ther. 2025 Sep 18.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Nat Biomed Eng. 2025 Apr 30.
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