Canine DNAM-1 / CD226 Protein, His Tag (SPR verified)

Canine DNAM-1, His Tag (DN1-C52H4) is expressed from human 293 cells (HEK293) . It contains AA Glu 32 - Gln 263 (Accession # E2R115-1) .

Product Specifications

Background

DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.2 kDa. The protein migrates as 36-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

E2R115-1

Expression Region

Glu 32 - Gln 263

Host

HEK293

Target

DNAM-1

Conjugation

Unconjugated

Tag

C-10xHis

Source

Canine

Stability

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.