Chrysophanol

Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.

Product Specifications

CAS Number

[481-74-3]

Product Name Alternative

Chrysophanic acid

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

EGFR

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Chrysophanol.html

Purity

99.77

Solubility

DMF : 4 mg/mL (ultrasonic) |DMSO : 2 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O

Molecular Formula

C15H10O4

Molecular Weight

254.24

Precautions

H315, H319, H335

References & Citations

[1]Lee MS, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25 (6) :833-7.|[2]Lim H, et al. Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol. 2016 Dec 8;7:476.