Chrysophanol
Product Specifications
UNSPSC Description
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.
Target Antigen
EGFR
Type
Natural Products
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Chrysophanol.html
Smiles
O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O
Molecular Weight
254.24
References & Citations
[1]Lee MS, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25(6):833-7.|[2]Lim H, et al. Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol. 2016 Dec 8;7:476.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13595/Chrysophanol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13595/Chrysophanol-SDS-MedChemExpress.pdf
CAS Number
481-74-3
Available Sizes
Curated Selection
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