Chrysophanol
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.
Product Specifications
CAS Number
[481-74-3]
Product Name Alternative
Chrysophanic acid
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
EGFR
Type
Natural Products
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Chrysophanol.html
Purity
99.77
Solubility
DMF : 4 mg/mL (ultrasonic) |DMSO : 2 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O
Molecular Formula
C15H10O4
Molecular Weight
254.24
Precautions
H315, H319, H335
References & Citations
[1]Lee MS, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25 (6) :833-7.|[2]Lim H, et al. Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol. 2016 Dec 8;7:476.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
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