Cephaeline (hydrochloride)

Cephaeline hydrochloride ((-) -Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections[1][2].

Product Specifications

CAS Number

[3738-70-3]

Product Name Alternative

(-) -Cephaeline (hydrochloride) ; NSC 32944 (monohydrochloride)

UNSPSC

12352005

Target

Filovirus; Flavivirus

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cephaeline-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC1=CC2=C([C@@H](C[C@@H]3[C@@H](CC)CN4CCC5=CC(OC)=C(OC)C=C5[C@]4([H])C3)NCC2)C=C1OC.[H]Cl

Molecular Formula

C28H39ClN2O4

Molecular Weight

503.07

References & Citations

[1]N.P.Sahu, et al. Determination of emetine and cephaeline in Ipecac roots by high- performance liquid chromatography. Journal of Chromatography A. 1982 Apr; 238 (2) :525-529.|[2]Yang S, et al. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 2018 Jun 5;4:31.