6-Amino-8-trifluoromethylphenanthridine
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (HY-135189) . It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM.2 6A-8tFP directly competes with protein substrates for the ribosomal active site.
Product Specifications
CAS Number
[651055-83-3]
Product Name Alternative
6A-8tFP
UNSPSC
12352005
Hazard Statement
H319
Target
Prion Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/6-amino-8-trifluoromethylphenanthridine.html
Smiles
NC1=C2C=C(C(F)(F)F)C=CC2=C(C=CC=C3)C3=N1
Molecular Formula
C14H9F3N2
Molecular Weight
262.23
Precautions
P264-P280-P305+P351+P338
References & Citations
[1]Bach, et al. Isolation of drugs active against mammalian prions using a yeast-based screening assay. Nat. Biotechnol. 21 (9), 1075-1081 (2003) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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