2-Hydroxychalcone
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].
Product Specifications
CAS Number
644-78-0
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; Bcl-2 Family; NF-κB; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-hydroxychalcone.html
Concentration
10mM
Purity
98.13
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2O
Molecular Formula
C15H12O2
Molecular Weight
224.25
Precautions
H315, H319
References & Citations
[1]Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203 (3) :565-72.|[2]B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58 (3) :526-34.|[3]BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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