2-Hydroxychalcone

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

Product Specifications

CAS Number

[644-78-0]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Apoptosis; Bcl-2 Family; NF-κB; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-hydroxychalcone.html

Concentration

10mM

Purity

98.13

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2O

Molecular Formula

C15H12O2

Molecular Weight

224.25

Precautions

H315, H319

References & Citations

[1]Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203 (3) :565-72.|[2]B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58 (3) :526-34.|[3]BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.