7-Nitroindazole

7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC50 = 0.47 μM in mouse cerebellum) . 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease[1][2][3][4].

Product Specifications

CAS Number

[2942-42-9]

UNSPSC

12352005

Hazard Statement

H301, H319, H351, H360

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/7-nitroindazole.html

Purity

99.09

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=[N+](C1=CC=CC2=C1NN=C2)[O-]

Molecular Formula

C7H5N3O2

Molecular Weight

163.14

Precautions

H301, H319, H351, H360

References & Citations

[1]Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108 (2) :296-7.|[2]Herrero MT, et al. 7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate. Open Biol. 2023 May;13 (5) :220370.|[3]Memarpour S, et al. Neuronal Nitric Oxide Inhibitor 7-Nitroindazole Improved Brain-Derived Neurotrophic Factor and Attenuated Brain Tissues Oxidative Damage and Learning and Memory Impairments of Hypothyroid Juvenile Rats. Neurochem Res. 2020 Nov;45 (11) :2775-2785.|[4]ilyavskii AI, et al. 7-Nitroindazole potentiates c-fos expression induced by muscle tendon vibration in the spinal cord. Muscle Nerve. 2012 Apr;45 (4) :597-602.