Dermorphin

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].

Product Specifications

CAS Number

[77614-16-5]

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Dermorphin.html

Purity

99.10

Solubility

H2O : ≥ 100 mg/mL

Smiles

OC(C=C1)=CC=C1C[C@H](NC(CNC([C@@H](NC([C@@H](C)NC([C@@H](N)CC2=CC=C(O)C=C2)=O)=O)CC3=CC=CC=C3)=O)=O)C(N4[C@@H](CCC4)C(N[C@@H](CO)C(N)=O)=O)=O

Molecular Formula

C40H50N8O10

Molecular Weight

802.87

References & Citations

[1]Tiwari V, et al. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. 2016 Mar;124 (3) :706-20.|[2]Bird MF, et al. Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo) . PLoS One. 2016 Jun 7;11 (6) :e0156897.