NAE-IN-2
NAE-IN-2 (compound III-26) is N2– (1-benzylpiperidin-4-yl) quinazoline-2,4-diamine derivative, and inhibits Cullin1 and Cullin3. NAE-IN-2 inhibits migration and induces cell apoptosis of gastric cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nae-in-2.html
Smiles
C1(CN2CCC(CC2)NC3=NC(NC4=CC5=C(C=NN5)C=C4)=C6C=CC=CC6=N3)=CC=CC=C1
Molecular Formula
C27H27N7
Molecular Weight
449.55
References & Citations
[1]Su J, et al. Discovery of the 2,4-disubstituted quinazoline derivative as a novel neddylation inhibitor for tumor therapy. Bioorg Chem. 2024;145:107237.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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