Hydrolyzed Fumonisin B1

Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719) . Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase[1][2][3].

Product Specifications

CAS Number

[145040-09-1]

Product Name Alternative

Aminopentol

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hydrolyzed-fumonisin-b1.html

Solubility

10 mM in DMSO

Smiles

C[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](O)[C@H](O)[C@H](C)CCCC

Molecular Formula

C22H47NO5

Molecular Weight

405.61

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Collins TF, et al. Effects of aminopentol on in utero development in rats. Food Chem Toxicol. 2006 Feb;44 (2) :161-9.|[2]Humpf HU, et al. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. J Biol Chem. 1998 Jul 24;273 (30) :19060-4.|[3]Schmelz EM, et al. Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol Appl Pharmacol. 1998 Feb;148 (2) :252-60.