1-Naphthohydroxamic acid
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM) . 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].
Product Specifications
CAS Number
6953-61-3
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-naphthohydroxamic-acid.html
Purity
99.59
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC=CC2=CC=C1)NO
Molecular Formula
C11H9NO2
Molecular Weight
187.19
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6; HDAC8
Available Sizes
Frequently Asked Questions
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