1-Naphthohydroxamic acid

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM) . 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].

Product Specifications

CAS Number

[6953-61-3]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-naphthohydroxamic-acid.html

Purity

99.59

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC=CC2=CC=C1)NO

Molecular Formula

C11H9NO2

Molecular Weight

187.19

Precautions

H302, H312, H332

References & Citations

[1]Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17 (10) :2874-8.|[2]Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1;15 (1) :91-9.