Adenine-15N5 (hydrochloride hydrate)

Adenine-15N5 hydrochloride hydrate (6-Aminopurine-15N5 hydrochloride hydrate) is the deuterium labeled Adenine (HY-B0152) . Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

Product Specifications

Product Name Alternative

6-Aminopurine-15N5 (hydrochloride hydrate) ; Vitamin B4-15N5 (hydrochloride hydrate)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/adenine-15n5-hydrochloride-hydrate.html

Smiles

[15NH2]C1=C2C([15NH]C=[15N]2)=[15N]C=[15N]1.Cl.O.[1/2]

Molecular Formula

C5H6Cl 15N5.1/2H2O

Molecular Weight

194.57

References & Citations

[1]ORO J, et al. Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide. Arch Biochem Biophys. 1961 Aug;94:217-27.|[2]Griffiths AJF, et al. An Introduction to Genetic Analysis. 7th edition. New York: W. H. Freeman; 2000. Structure of DNA.|[3]Reader V. The assay of vitamin B (4) . Biochem J. 1930;24 (6) :1827-31.|[4]Yung-Jen Tsai, et al. Pharmacokinetics of Adenosine and Cordycepin, a Bioactive Constituent of Cordyceps sinensis in Rat. J Agric Food Chem 2010 Apr 28;58 (8) :4638-43.|[5]Fatma F Mohamed, et al. Dentoalveolar Alterations in an Adenine‐Induced Chronic Kidney Disease Mouse Model. J Bone Miner Res. 2023 Aug;38 (8) :1192-1207.|[6]Chien-Ning Hsu, et al. Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease. Antioxidants (Basel) . 2022 Jan 11;11 (1) :147.