FICZ
Product Specifications
Product Name Alternative
6-Formylindolo[3,2-b]carbazole
UNSPSC Description
FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.
Target Antigen
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/FICZ.html
Purity
99.42
Solubility
DMSO : 10 mg/mL (ultrasonic;warming)
Smiles
O=CC1=C2C(NC3=C2C=CC=C3)=CC4=C1NC5=C4C=CC=C5
Molecular Weight
284.31
References & Citations
[1]Mohammadi-Bardbori A, et al. The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro. Arch Toxicol. 2017 Mar 13|[2]Farmahin R, et al. Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time. Biochem Pharmacol. 2016 Sep 1;115:134-43|[3]Smith BW, et al. Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells Int. 2016;2016:2574152.|[4]Wincent E, et al. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol. 2016 Jun 15;110-111:117-29.|[5]N A Davarinos, et al. Aryl Hydrocarbon Receptor Imported Into the Nucleus Following Ligand Binding Is Rapidly Degraded via the Cytosplasmic Proteasome Following Nuclear Export. J Biol Chem. 1999 Oct 1;274(40):28708-15.|[6]Riccardo Sibilano, et al. The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses. J Immunol. 2012 Jul 1;189(1):120-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12451/FICZ-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12451/FICZ-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
172922-91-7
Available Sizes
Curated Selection
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