Hydrocortisone
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].
Product Specifications
CAS Number
50-23-7
Product Name Alternative
Cortisol
UNSPSC
12352211
Hazard Statement
H360, H373
Target
Endogenous Metabolite; Glucocorticoid Receptor
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology; Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Hydrocortisone.html
Purity
99.94
Solubility
DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@@H](O)C1
Molecular Formula
C21H30O5
Molecular Weight
362.46
Precautions
H360, H373
References & Citations
[1]Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586 (7) :1937-49.|[2]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108 (2) :242-9.|[3]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107 (5) :776-84.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Available Sizes
Frequently Asked Questions
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